Founder of the social networking website MySpace, Anderson co-founded the site in 2003 with Chris DeWolfe. Anderson has served as president of MySpace, and later became a strategic adviser for the company. Because newly created MySpace accounts previously included Tom as a default "friend," he became known as the default picture of MySpace. As of February 2010, Anderson's profile had over 12 million friends.
In 2003, working for eUniverse under the purview of Brad Greenspan, he and a few other eUniverse employees set up the first pages of MySpace, and the site grew from there. It was at the time one of the most popular social networking websites in the United States, listing consistently among the top ten on Alexa Top 500 Global Sites, after its main competitor, Facebook.
Anderson briefly appeared in the 2009 American drama-comedy Funny People, starring Adam Sandler, Seth Rogen, and Leslie Mann.
American Idol finalist Scott MacIntyre wrote a song called "I'll Take Tom" on his debut album Heartstrings. The song was written about a MySpace relationship.
